[noo-klee-eys, -eyz, nyoo-]

noun Biochemistry.

any enzyme that catalyzes the hydrolysis of nucleic acids.

Origin of nuclease

1900–05; nucle(ic) + -ase Unabridged Based on the Random House Unabridged Dictionary, © Random House, Inc. 2019

British Dictionary definitions for nuclease



any of a group of enzymes that hydrolyse nucleic acids to simple nucleotides
Collins English Dictionary - Complete & Unabridged 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

nuclease in Medicine


[nōōklē-ās′, -āz′]


Any of several enzymes, such as endonuclease and exonuclease, that hydrolize nucleic acids.
The American Heritage® Stedman's Medical Dictionary Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.