• synonyms


[noo-klee-uh-fil-ik, nyoo-]
adjective Chemistry.
  1. of or relating to electron contribution in covalent bonding (opposed to electrophilic).
Show More

Origin of nucleophilic

First recorded in 1930–35; nucleo- + -philic
Related formsnu·cle·o·phile [noo-klee-uh-fahyl, nyoo-] /ˈnu kli əˌfaɪl, ˈnyu-/, noun
Dictionary.com Unabridged Based on the Random House Unabridged Dictionary, © Random House, Inc. 2018

British Dictionary definitions for nucleophile


  1. chem having or involving an affinity for positive charge. Nucleophilic reagents (nucleophiles) are molecules, atoms, and ions that behave as electron donorsCompare electrophilic
Show More
Collins English Dictionary - Complete & Unabridged 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

nucleophile in Medicine


  1. A chemical compound or group that is attracted to nuclei and tends to donate or share electrons.
Show More
Related formsnu′cle•o•philic (-fĭlĭk) adj.
The American Heritage® Stedman's Medical Dictionary Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.