nucleosome

American  

[noo-klee-uh-sohm, nyoo-] / ˈnu kli əˌsoʊm, ˈnju- /

noun

Cell Biology.

1. any of the repeating subunits of chromatin occurring at intervals along a strand of DNA, consisting of DNA coiled around histone.

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nucleosome British  

/ ˈnjuːklɪəˌsəʊm /

noun

1. a repeating structural unit of chromatin that contains DNA and histones

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nucleosome Scientific  

/ no̅o̅′klē-ə-sōm′ /

1. Any of the repeating subunits of chromatin in eukaryotic cells, consisting of a DNA chain coiled around a core of histones.

2. See Note at histone

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Etymology

Origin of nucleosome

First recorded in 1960–65; nucleo- + -some ³

Example Sentences

See Examples For:

nucleosome

Each nucleosome consists of approximately 147 base pairs of DNA wrapped around a histone octamer which is composed of two H2A-H2B dimers and one H3-H4 tetramer.

From Science Daily ● Mar. 7, 2024

Notably, they observed that Spt16, a component of FACT, captures the histones that have been completely stripped off the duplex DNA from the parental nucleosome.

From Science Daily ● Mar. 7, 2024

Why is nucleosome formation required for the packaging of DNA?

From Textbooks ● Jun. 9, 2022

Each beadlike histone-DNA complex is called a nucleosome, and DNA connecting the nucleosomes is called linker DNA.

From Textbooks ● Jun. 9, 2022

In this first application of single-cell RNA sequencing to a eukaryotic pathogen, Bjrn Kafsack and colleagues determine the transcriptional changes induced by AP2-G, identifying other AP2 transcription factors, histone-modifying enzymes and regulators of nucleosome positioning.

From Nature ● Sep. 24, 2017