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base editing

American  
[bays ed-it-ing] / ˈbeɪs ˌɛd ɪt ɪŋ /

noun

  1. Genetics. a precise gene editing technique in which a single base or nucleotide (represented by a letter) is replaced by another in the sequence of a piece of DNA.


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Example Sentences

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Speaking of gene editing, Columbia University researchers successfully demonstrated base editing of “early human embryos” to replace specific genetic letters.

From The Wall Street Journal ● Jun. 21, 2026

A DNA-editing technique, base editing, was used on early-stage embryos to fix disease-causing mutations.

From The Wall Street Journal ● Jun. 5, 2026

Li then used base editing to create targeted amino acid changes in cancer cells.

From Science Daily ● Oct. 5, 2023

Dr David Liu, one of the inventors of base editing at the Broad Institute, told me it was "a bit surreal" that people were being treated just six years after the technology was invented.

From BBC ● Dec. 10, 2022

In July, the company Verve Therapeutics began a clinical study of a CRISPR-based approach called base editing for an inherited form of high cholesterol driven by an overactive gene called PCSK9.

From Science Magazine ● Sep. 16, 2022

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