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prefrontal

American

[pree-fruhn-tl] / priˈfrʌn tl /

adjective

Anatomy.

anterior to, situated in, or pertaining to the anterior part of a frontal structure.

prefrontal British

/ priːˈfrʌntəl /

adjective

situated in, involving, or relating to the foremost part of the frontal lobe of the brain

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

Etymology

Origin of prefrontal

First recorded in 1850–55; pre- + frontal

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

Even before I first saw the film during last year’s Sundance Film Festival, this one-line elevator pitch was taking up all the space in my prefrontal cortex.

From Salon • Feb. 18, 2026

Most current treatments improve attention by increasing activity in brain circuits that control focus, especially in the prefrontal cortex.

From Science Daily • Jan. 2, 2026

Current treatments for attention disorders typically increase excitatory signaling in prefrontal brain circuits using stimulant medications.

From Science Daily • Jan. 2, 2026

This reduction was most clearly seen in the prefrontal cortex, a region involved in thinking, emotional regulation and decision-making.

From Science Daily • Dec. 4, 2025

“Now someone tell me what they observe about Ms. Prior’s lateral prefrontal cortex.”

From "Insurgent" by Veronica Roth

Definitions and idiom definitions from Dictionary.com Unabridged, based on the Random House Unabridged Dictionary, © Random House, Inc. 2023