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proinsulin

American  
[proh-in-suh-lin, -ins-yuh-] / proʊˈɪn sə lɪn, -ˈɪns jə- /

noun

Biochemistry.
  1. the prohormone of insulin, converted into insulin by enzymatic removal of part of the molecule.


Etymology

Origin of proinsulin

First recorded in 1915–20; pro- 1 + insulin

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

See Examples For:

"Our studies highlight that proinsulin folding is vulnerable to many of the same cellular stresses that cause beta cell failure in type 2 diabetes," said Kaufman.

From Science Daily Jul. 28, 2026

No current therapies are designed to improve proinsulin folding in order to preserve the health and function of beta cells.

From Science Daily Jul. 28, 2026

Previous research has linked this decline to the misfolding of proinsulin, the precursor protein cells use to make insulin.

From Science Daily Jul. 28, 2026

Reintroducing the protein improved the cells' ability to fold and transport proinsulin while reducing the accumulation of improperly folded copies.

From Science Daily Jul. 28, 2026

Wheeler's colleagues in Brazil inserted a segment of human DNA coding for proinsulin -- the protein precursor of the active form of insulin -- into cell nuclei of 10 cow embryos.

From Science Daily Mar. 13, 2024

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