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proinsulin

American

[proh-in-suh-lin, -ins-yuh-] / proʊˈɪn sə lɪn, -ˈɪns jə- /

noun

Biochemistry.

the prohormone of insulin, converted into insulin by enzymatic removal of part of the molecule.

Etymology

Origin of proinsulin

First recorded in 1915–20; pro- ¹ + insulin

Example Sentences

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See Examples For:

proinsulin

No current therapies are designed to improve proinsulin folding in order to preserve the health and function of beta cells.

From Science Daily ● Jul. 28, 2026

Previous research has linked this decline to the misfolding of proinsulin, the precursor protein cells use to make insulin.

From Science Daily ● Jul. 28, 2026

"Our studies highlight that proinsulin folding is vulnerable to many of the same cellular stresses that cause beta cell failure in type 2 diabetes," said Kaufman.

From Science Daily ● Jul. 28, 2026

Scientists already knew that improperly folded proinsulin accumulates during diabetes and places stress on pancreatic beta cells.

From Science Daily ● Jul. 28, 2026

The team identified several biomarkers related to insulin resistance -- such as fasting insulin, insulin at 30 minutes and 120 minutes, proinsulin, and serum C-peptide -- that were associated with increased AS risk.

From Science Daily ● Nov. 27, 2024

Definitions and idiom definitions from Dictionary.com Unabridged, based on the Random House Unabridged Dictionary, © Random House, Inc. 2023