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proinsulin

American

[proh-in-suh-lin, -ins-yuh-] / proʊˈɪn sə lɪn, -ˈɪns jə- /

noun

Biochemistry.

the prohormone of insulin, converted into insulin by enzymatic removal of part of the molecule.

Etymology

Origin of proinsulin

First recorded in 1915–20; pro- ¹ + insulin

Example Sentences

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proinsulin

Scientists already knew that improperly folded proinsulin accumulates during diabetes and places stress on pancreatic beta cells.

From Science Daily ● Jul. 28, 2026

"Our goal was to examine how these partner proteins coordinate proinsulin folding and remove any misfolded mistakes, as these steps are essential for the health of insulin-producing cells."

From Science Daily ● Jul. 28, 2026

When cells produced extra BiP but lacked p58IPK, they showed only modest gains in proinsulin folding and its movement out of the cell.

From Science Daily ● Jul. 28, 2026

The investigators also identified additional partner proteins involved in folding and transporting proinsulin, as well as detecting and managing misfolded versions.

From Science Daily ● Jul. 28, 2026

Still, human proinsulin and, surprisingly, insulin were detectable in the milk.

From Science Daily ● Mar. 13, 2024

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Definitions and idiom definitions from Dictionary.com Unabridged, based on the Random House Unabridged Dictionary, © Random House, Inc. 2023