prothrombin

American  

[proh-throm-bin] / proʊˈθrɒm bɪn /

noun

Biochemistry.

1. a plasma protein involved in blood coagulation that on activation by factors in the plasma is converted to thrombin.

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prothrombin British  

/ prəʊˈθrɒmbɪn /

noun

1. biochem a zymogen found in blood that gives rise to thrombin on activation See also phylloquinone

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prothrombin Scientific  

/ prō-thrŏm′bĭn /

1. A glycoprotein that is converted to thrombin during blood clotting. Prothrombin is formed by and stored in the liver.

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Etymology

Origin of prothrombin

First recorded in 1895–1900; pro- ¹ + thrombin

Example Sentences

I had barely removed my coat before the doctor started rattling off the things I had tested negative for: antiphospholipid antibodies, lupus anticoagulant, Factor V Leiden, prothrombin gene mutation.

From The Guardian • May 5, 2020

We physicians should see a record of her prothrombin times to assess adequacy of control.

From Washington Post • Sep. 9, 2016

And as noted earlier, basophils release heparin, a short-acting anticoagulant that also opposes prothrombin.

From Textbooks • Jun. 19, 2013

Once factor X has been activated by either the intrinsic or extrinsic pathway, the enzyme prothrombinase converts factor II, the inactive enzyme prothrombin, into the active enzyme thrombin.

From Textbooks • Jun. 19, 2013

The interaction of these two bodies next results in the formation of prothrombin, which, combining with the calcium of any soluble lime salt present, forms thrombin or fibrin-ferment.

From Encyclopaedia Britannica, 11th Edition, Volume 4, Slice 1 "Bisharin" to "Bohea" by Various