prothrombin

American  

[proh-throm-bin] / proʊˈθrɒm bɪn /

noun

Biochemistry.

1. a plasma protein involved in blood coagulation that on activation by factors in the plasma is converted to thrombin.

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prothrombin British  

/ prəʊˈθrɒmbɪn /

noun

1. biochem a zymogen found in blood that gives rise to thrombin on activation See also phylloquinone

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prothrombin Scientific  

/ prō-thrŏm′bĭn /

1. A glycoprotein that is converted to thrombin during blood clotting. Prothrombin is formed by and stored in the liver.

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Etymology

Origin of prothrombin

First recorded in 1895–1900; pro- ¹ + thrombin

Example Sentences

I had barely removed my coat before the doctor started rattling off the things I had tested negative for: antiphospholipid antibodies, lupus anticoagulant, Factor V Leiden, prothrombin gene mutation.

From The Guardian • May 5, 2020

We physicians should see a record of her prothrombin times to assess adequacy of control.

From Washington Post • Sep. 9, 2016

And as noted earlier, basophils release heparin, a short-acting anticoagulant that also opposes prothrombin.

From Textbooks • Jun. 19, 2013

Once factor X has been activated by either the intrinsic or extrinsic pathway, the enzyme prothrombinase converts factor II, the inactive enzyme prothrombin, into the active enzyme thrombin.

From Textbooks • Jun. 19, 2013

It has been shown that the final step in its formation consists in the combination of another substance, termed prothrombin, with calcium.

From Encyclopaedia Britannica, 11th Edition, Volume 4, Slice 1 "Bisharin" to "Bohea" by Various