quinolone

American  

[kwin-uh-lohn] / ˈkwɪn ə loʊn /

noun

Pharmacology.

1. a synthetic broad-spectrum antibiotic, derived from hydroxylated quinoline, that suppresses the reproduction of bacteria by inhibiting DNA replication.

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quinolone British  

/ ˈkwɪnəˌləʊn /

noun

1. any of a group of synthetic antibiotics, including ciprofloxacin, that inactivate an enzyme required for the replication of certain microorganisms

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quinolone Scientific  

/ kwĭn′ə-lōn′ /

1. Any of a class of synthetic antibiotics that inhibit the replication of bacterial DNA.

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Etymology

Origin of quinolone

First recorded in 1890–95; quinol(ine) ( def. ) + -one ( def. )

Example Sentences

Quinolone antibiotics, first developed in the 1960s, kill bacteria by blocking enzymes called class II topoisomerases, which normally untangle DNA during cell replication.

From Nature

It helped to trigger a wave of reports on websites such as the Quinolone Antibiotics Adverse Reaction Forum, which by 2001 hosted more than 5,000 posts.

From Nature

Helping coordinate the effort is the patient advocacy group Quinolone Vigilance Foundation.

From Washington Post

In 2013, one-quarter of campylobacter samples from sick people were resistant to quinolone antibiotics such as ciprofloxacin, the agency said.

From US News

However, the rate of resistance to quinolone drugs in Salmonella typhi -- which causes typhoid fever -- rose to 68 percent in 2012.

From US News