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St. Louis

American  
[seynt loo-is] / ˌseɪnt ˈlu ɪs /

noun

  1. a port in E Missouri, on the Mississippi.

  2. a river in NE Minnesota, flowing generally S to Lake Superior at Duluth. 160 miles (257 km) long.


St. Louis Cultural  
  1. The largest city in Missouri.


Discover More

Known as the “Gateway to the West” because of its importance as a staging area for wagon trains in the nineteenth century. The Gateway Arch, made of steel and several hundred feet high, stands in St. Louis in commemoration of this fact.

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

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Gilliam once took Baker to eat lunch at Negro League legend Cool Papa Bell’s home in St. Louis.

From Los Angeles Times Jul. 28, 2026

The lead lawyer for Trump’s petitions to the Supreme Court in the Carroll cases had been Justin Smith, until recently an attorney at the St. Louis, Mo.-based boutique James Otis Law Group.

From The Wall Street Journal Jul. 10, 2026

A new study from Washington University School of Medicine in St. Louis has uncovered an unexpected feature of how these cancer vaccines work.

From Science Daily Jul. 9, 2026

Average U.S. ground-beef prices have hovered near $7 a pound, according to data from the Federal Reserve Bank of St. Louis.

From MarketWatch Jul. 7, 2026

She dreamed she was standing at the top of the steepest hill in Forest Park, St. Louis, in front of the art museum, on a fresh morning of new snow.

From "Habibi" by Naomi Shihab Nye

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