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SSRI

American  

abbreviation

Pharmacology.
  1. selective serotonin reuptake inhibitor: a class of drugs that prolong the action of serotonin in the brain by inhibiting its reabsorption by neurons, used mainly to treat depression.


SSRI British  

abbreviation

  1. selective serotonin reuptake inhibitor; any of a class of drugs, including fluvoxamine, paroxetine, fluoxetine (Prozac), and Lustral, that increase concentrations of serotonin in the brain: used in the treatment of depression

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

SSRI Scientific  
/ ĕs′ĕs-är-ī /
  1. Short for selective serotonin reuptake inhibitor. Any of a class of drugs that inhibit the uptake of serotonin in the central nervous system and are used to treat depression and other psychiatric disorders.


Etymology

Origin of SSRI

First recorded in 1990–95

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

See Examples For:

"We used these organoids to model how some patients' tissue may respond to a commonly prescribed SSRI," Machairaki says.

From Science Daily Jul. 22, 2026

Erritzoe hopes his next study will help inform which patients are likely to respond to an SSRI.

From Salon May 23, 2025

It took therapy, an SSRI, and years of practice to get to a significantly better place with it and related activities, like job interviews or big meetings.

From Slate Sep. 10, 2023

If depression were caused by a deficit of serotonin, you’d feel better in a day or so after taking an SSRI.

From Washington Post Oct. 10, 2022

Essentially, the framework suggested a clinical algorithm: If you want to change the brain’s emotional bias, use an SSRI.

From Scientific American Jun. 21, 2017

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