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St. Louis

American  
[seynt loo-is] / ˌseɪnt ˈlu ɪs /

noun

  1. a port in E Missouri, on the Mississippi.

  2. a river in NE Minnesota, flowing generally S to Lake Superior at Duluth. 160 miles (257 km) long.


St. Louis Cultural  
  1. The largest city in Missouri.


Discover More

Known as the “Gateway to the West” because of its importance as a staging area for wagon trains in the nineteenth century. The Gateway Arch, made of steel and several hundred feet high, stands in St. Louis in commemoration of this fact.

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

See Examples For:

St. Louis shelled out for the broker’s fee—she figured it would pay off given how long she plans to stay there.

From The Wall Street Journal Aug. 31, 2026

Lionel Richie was hospitalized after a performance in St. Louis on Saturday.

From Los Angeles Times Aug. 31, 2026

Scientists at Washington University School of Medicine in St. Louis and Princeton University have now identified a biological process that may help explain how early trauma can have such long-lasting effects on the brain.

From Science Daily Aug. 26, 2026

Heyward leveraged that platform season in St. Louis into an eight-year free agent contract with the Cubs worth $184 million, setting a franchise record.

From Los Angeles Times Aug. 25, 2026

Poppy whispered back, “Who knows? Maybe they think he’s our next-door neighbor from St. Louis, since he’s only speaking English. I just said he was our friend.”

From "Habibi" by Naomi Shihab Nye

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