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St. Louis

American  
[seynt loo-is] / ˌseɪnt ˈlu ɪs /

noun

  1. a port in E Missouri, on the Mississippi.

  2. a river in NE Minnesota, flowing generally S to Lake Superior at Duluth. 160 miles (257 km) long.


St. Louis Cultural  
  1. The largest city in Missouri.


Discover More

Known as the “Gateway to the West” because of its importance as a staging area for wagon trains in the nineteenth century. The Gateway Arch, made of steel and several hundred feet high, stands in St. Louis in commemoration of this fact.

Example Sentences

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The lead lawyer for Trump’s petitions to the Supreme Court in the Carroll cases had been Justin Smith, until recently an attorney at the St. Louis, Mo.-based boutique James Otis Law Group.

From The Wall Street Journal Jul. 10, 2026

A new study from Washington University School of Medicine in St. Louis has uncovered an unexpected feature of how these cancer vaccines work.

From Science Daily Jul. 9, 2026

The last time the Angels hired an experienced general manager from outside the organization: 35 years ago, when they also looked to St. Louis for Whitey Herzog.

From Los Angeles Times Jul. 6, 2026

And he began his major-league career with the St. Louis Cardinals as a 20-year-old with a historic 12-game hitting streak, establishing himself as one of the sport’s most coveted prospects.

From The Wall Street Journal Jul. 1, 2026

He wrote it when he made a stop in St. Louis during his cross-country trip.

From Nazi Saboteurs by Samantha Seiple

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