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St. Louis

American  
[seynt loo-is] / ˌseɪnt ˈlu ɪs /

noun

  1. a port in E Missouri, on the Mississippi.

  2. a river in NE Minnesota, flowing generally S to Lake Superior at Duluth. 160 miles (257 km) long.


St. Louis Cultural  
  1. The largest city in Missouri.


Discover More

Known as the “Gateway to the West” because of its importance as a staging area for wagon trains in the nineteenth century. The Gateway Arch, made of steel and several hundred feet high, stands in St. Louis in commemoration of this fact.

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

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Gilliam once took Baker to eat lunch at Negro League legend Cool Papa Bell’s home in St. Louis.

From Los Angeles Times Jul. 28, 2026

“I don’t know how everybody in the stadium knew how to do it,” the St. Louis Cardinals outfielder said Wednesday at Angel Stadium.

From Los Angeles Times Jul. 22, 2026

Top schools including Tulane University, Washington University in St. Louis and the University of North Carolina at Chapel Hill are reducing the number of essays applicants have to submit.

From The Wall Street Journal Jul. 10, 2026

A new study from Washington University School of Medicine in St. Louis has uncovered an unexpected feature of how these cancer vaccines work.

From Science Daily Jul. 9, 2026

Next Holmes traveled to St. Louis, where the Pitezel family now lived.

From "The Devil in the White City" by Erik Larson

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