substantia nigra

American  

[suhb-stan-shee-uh nahy-gruh, nig-ruh] / səbˈstæn ʃi ə ˈnaɪ grə, ˈnɪg rə /

noun

plural

substantiae nigrae, substantia nigras

1. a deeply pigmented area of the midbrain containing dopamine-producing nerve cells.

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substantia nigra British  

/ səbˈstænʃə ˈnaɪɡrə /

noun

1. a layer of grey matter in the brain that produces dopamine and contains pigmented nerve cells, loss of which has been associated with Parkinson's disease

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Etymology

Origin of substantia nigra

1880–85; < New Latin: black substance

Example Sentences

The research, conducted in Parkinson's disease patients undergoing brain surgery while awake, homed in on the brain's substantia nigra, a crucial area associated with motor control and reward processing.

From Science Daily • Feb. 26, 2024

In rodents exposed to TCE, the dopamine-generating neurons in the midbrain’s substantia nigra are destroyed, as happens in human Parkinson’s disease.

From Science Magazine • May 15, 2023

This conversion increases the overall level of dopamine neurotransmission and can help compensate for the loss of dopaminergic neurons in the substantia nigra.

From Textbooks • Jun. 9, 2022

It affects neurons in a specific area of the brain called the substantia nigra.

From BBC • Mar. 31, 2022

It is thought to depend upon some connexion, not yet anatomically demonstrated, between the third cranial nerve and its nucleus in the floor of the iter and the substantia nigra.

From The Project Gutenberg Encyclopedia Volume 1 of 28 by Project Gutenberg