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supercoiling

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Some DNA supercoiling is essential to make DNA accessible to allow the cell to read and make copies of the genetic information, but either too little or too much supercoiling is detrimental.

From Science Daily Apr. 11, 2024

Fortunately, cells have an ingenious solution to carefully regulate DNA supercoiling.

From Science Daily Apr. 11, 2024

The opening of the double helix causes over-winding, or supercoiling, in the DNA ahead of the replication fork.

From Textbooks Jun. 9, 2022

Topoisomerase relieves the pressure that results from supercoiling by breaking and reforming DNA’s phosphate backbone ahead of the replication fork.

From Textbooks Jun. 9, 2022

Peter Pauling arrived with the inside news that his father was preoccupied with schemes for the supercoiling of a-helices in the hair protein, keratin.

From "Double Helix" by James D. Watson