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Synonyms

systemic

American  
[si-stem-ik] / sɪˈstɛm ɪk /

adjective

  1. of or relating to a system, especially when affecting the entirety of a thing.

    systemic flaws in the design and construction of the vehicles.

  2. relating to or noting a policy, practice, or set of beliefs that has been established as normative or customary throughout a political, social, or economic system: systemic racism.

    systemic inequality;

    systemic racism.

  3. Physiology, Pathology.

    1. relating to or affecting the body as a whole.

    2. relating to or affecting a particular body system.

  4. (of a pesticide) absorbed and circulated by a plant or other organism so as to be lethal to pests that feed on it.


systemic British  
/ -ˈstiː-, sɪˈstɛmɪk /

adjective

  1. another word for systematic systematic

  2. physiol (of a poison, disease, etc) affecting the entire body

  3. (of a pesticide, fungicide, etc) spreading through all the parts of a plant and making it toxic to pests or parasites without destroying it

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

noun

  1. a systemic pesticide, fungicide, etc

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

Other Word Forms

  • nonsystemic adjective
  • systemically adverb

Etymology

Origin of systemic

First recorded in 1795–1805; system + -ic

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

“It is a systemic shock that moves through the infrastructure of everyday life, from power plants to irrigation canals, and ultimately to food security.”

From The Wall Street Journal

A 2025 scientific statement from the American Heart Association on risk-based primary prevention of heart failure highlights systemic inflammation, or inflammation throughout the body, as a major contributor to heart disease.

From Science Daily

"Our future goal is to create the next generation of tissue-specific therapies that preserve therapeutic benefit while reducing unintended systemic effects," said Elgendy.

From Science Daily

Such family structures, experts say, can face systemic barriers in housing, healthcare, education and other services where existing policies often assume dual income or nuclear households.

From Los Angeles Times

On top of that, nearly two-thirds of respondents said private equity and private credit markets would be the most likely source of a systemic credit event.

From Barron's