tumor suppressor gene

1. A gene that suppresses cellular proliferation. When inherited in a mutated state in which it is no longer suppressive, it is associated with the development of various cancers, including most familial cancers.

Example Sentences

One of these genes -- the tumor suppressor gene TP53 - plays a key role.

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The researchers demonstrated their technique by screening cells with more than 1,000 different mutations of the tumor suppressor gene p53, all of which have been seen in cancer patients.

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However, the authors uncovered that cell membrane damage induces cellular senescence via a different mechanism that involves calcium ions and the tumor suppressor gene p53.

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That led him to his “two-hit” hypothesis, and his insight that cancer sometimes results not from a particular cause, but rather from the disabling of something known today as the tumor suppressor gene.

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In this study, researchers zeroed in on a specific variant in a tumor suppressor gene that is mutated and activated in most cancers.

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