tumor suppressor gene

American  

[toom-er-suh-pres-er jeen] / ˈtum ər səˈprɛs ər ˌdʒin /

noun

plural

tumor suppressor genes

1. any of a group of genes that prevent uncontrolled cell division, unless the gene is rendered inactive through mutation.

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tumor suppressor gene Scientific  

1. A gene that suppresses cellular proliferation. When inherited in a mutated state in which it is no longer suppressive, it is associated with the development of various cancers, including most familial cancers.

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Example Sentences

Additionally, it reveals the intricate connection between NMD and the most famous tumor suppressor gene, p53, suggesting possible new connections between NMD and cancer.

From Science Daily • May 1, 2024

"Is this a tumor suppressor gene? Is this an oncogene? Does it collaborate with gene XY? You can play the kind of games on the scale that you always wanted to," he says.

From Science Magazine • Aug. 23, 2017

He hopes the project will help scientists develop a synthetic version of the tumor suppressor gene known as p53.

From Slate • May 4, 2016

Nearly 25 years ago, Dr. Brash and his co-workers reported that UV light induced mutations in the critically important tumor suppressor gene called p53.

From New York Times • Jun. 29, 2015

Research into HPV eventually uncovered how Henrietta’s cancer started: HPV inserted its DNA into the long arm of her eleventh chromosome and essentially turned off her p 5 3 tumor suppressor gene.

From "The Immortal Life of Henrietta Lacks" by Rebecca Skloot