[yoo r-uh-kahy-neys, -neyz]

noun Biochemistry, Pharmacology.

an enzyme, present in the blood and urine of mammals, that activates plasminogen and is used medicinally to dissolve blood clots.

Origin of urokinase

First recorded in 1955–60; uro-1 + kinase
Dictionary.com Unabridged Based on the Random House Unabridged Dictionary, © Random House, Inc. 2019

Medicine definitions for urokinase


[yur′ō-kīnās, -nāz]


An enzyme that catalyzes the conversion of plasminogen to plasmin and is produced in the kidney, excreted in the urine, and used to dissolve blood clots.plasminogen activator
The American Heritage® Stedman's Medical Dictionary Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.