Acronyms dictionary FLOTUS What does FLOTUS mean? FLOTUS is an acronym for First Lady of the United States. It’s a common, informal acronym. First Lady Melania Trump uses the Twitter handle @FLOTUS. Michelle Obama just used @MichelleObama … Examples of FLOTUS Trump has taken an inconspicuous approach to her job compared with some of her predecessors, in part because she didn't become a full-time FLOTUS until June 2017. Maria Puente, USA Today, May, 2018 Melania Trump is an unusual First Lady. She is only the second FLOTUS in history not to have been born in the U.S. Sarah Ellison, Vanity Fair, 2017 OMG Liberal Freaks leave our #FLOTUS alone! @vivanari, June, 2018 SEE MORE EXAMPLES Who uses FLOTUS? me.me Just Added bystander effect, CSI effect, Streisand effect, L + ratio, docufiction Note This is not meant to be a formal definition of FLOTUS like most terms we define on Dictionary.com, but is rather an informal word summary that hopefully touches upon the key aspects of the meaning and usage of FLOTUS that will help our users expand their word mastery.