Acronyms dictionary OPP What does OPP mean? OPP is an acronym that refers to sexual infidelity, meaning other people’s pussy. It is the title and topic of a 1991 song by the rap group Naughty by Nature. Not an acronym but commonly used, OPP can also stand for opposition, or enemy, and is often used in street and gang culture. Related words: thug life YMCMB Examples of OPP Person 1: she's hot but ... Person 2: yeah, don't mess with OPP! I wanted to talk to you about this slang term “opp” because I follow you on Twitter and you’re constantly calling people opps on there. Miles Raymer, Interview with Katie Got Bandz on Vice.com, December, 2012 Spot an OPP then we get him dead Lyrics, "How We Move," by Lil Bibby ft. King Louie SEE MORE EXAMPLES Who uses OPP? Just Added frito pie, walking taco, .5 selfie, pinkwashing, revenge travel Note This is not meant to be a formal definition of OPP like most terms we define on Dictionary.com, but is rather an informal word summary that hopefully touches upon the key aspects of the meaning and usage of OPP that will help our users expand their word mastery.