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[pahy-ruh-juh n, -jen] /ˈpaɪ rə dʒən, -ˌdʒɛn/
a substance, as a thermostable bacterial toxin, that produces a rise in temperature in a human or animal.
Origin of pyrogen
First recorded in 1855-60; pyro- + -gen Unabridged
Based on the Random House Dictionary, © Random House, Inc. 2018.
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British Dictionary definitions for pyrogen


any of a group of substances that cause a rise in temperature in an animal body
Collins English Dictionary - Complete & Unabridged 2012 Digital Edition
© William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins
Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012
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Word Origin and History for pyrogen

1858, as a proposed word for "electricity," from pyro- + -gen. Meaning "fever-producer" is from 1896. Related: Pyrogenic; pyrogenetic. Greek pyrogenes meant "born in fire, wrought by fire."

Online Etymology Dictionary, © 2010 Douglas Harper
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pyrogen in Medicine

pyrogen py·ro·gen (pī'rə-jən)
A substance that produces a fever.

The American Heritage® Stedman's Medical Dictionary
Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.
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pyrogen in Science
A polypeptide that produces fever by causing metabolic changes in the hypothalamus. Pyrogens are either exogenous (produced by infectious agents) or endogenous (produced by cells in the body such as macrophages).
The American Heritage® Science Dictionary
Copyright © 2002. Published by Houghton Mifflin. All rights reserved.
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