Diagnosed with refractory acute myeloid leukemia at age 7, Sam was very brave but also very sick.
On the 23rd of November, still more unequivocal symptoms of a refractory spirit appeared in the Irish parliament.
No temper is exactly sunny after a struggle with a refractory engine.
He rode back a short distance, and used all the arts of his horsemanship to reduce his refractory steed to obedience.
Lately, he had been somewhat depressed by his encounter with refractory wills.
My arms ache; the mob of slaves get more and more dirty and refractory.
He had the air of a schoolmaster reproving a refractory pupil.
He remonstrated with the Judan fathers, he even cursed them, and finally caused the refractory to be punished.
She tugs and pulls, and thumps the refractory thing on the floor.
The most refractory male is always forced to lower his standard before the conquering arms of woman.
"stubborn, obstinate, perverse," 1610s (earlier refractorious, 1550s, refractary, c.1600), from Latin refractarius "obstinate, stubborn," from past participle stem of refringere (see refraction). Related: Refractorily; refractoriness.
refractory re·frac·to·ry (rĭ-frāk'tə-rē)
Resistant to treatment, as a disease.
Unresponsive to stimuli, as a muscle or nerve fiber.