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antidepressant

American  
[an-tee-di-pres-uhnt, an-tahy-] / ˌæn ti dɪˈprɛs ənt, ˌæn taɪ- /
Also anti-depressant,

adjective

  1. of or relating to a substance that is used in the treatment of mood disorders, as characterized by various manic or depressive affects.


noun

  • antidepressants
    plural
  1. Also called energizer, psychic energizer.  any such substance, as a tricyclic antidepressant, MAO inhibitor, or lithium.

antidepressant British  
/ ˌæntɪdɪˈprɛsənt /

noun

  1. any of a class of drugs used to alleviate depression

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

adjective

  1. of or relating to this class of drugs

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012
antidepressant Scientific  
/ ăn′tē-dĭ-prĕsənt,ăn′tī- /
  1. A drug used to prevent or treat depression.


Other Word Forms

Noun Inflected Forms

Etymology

Origin of antidepressant

First recorded in 1960–65; anti- + depressant

Explanation

An antidepressant is a drug used to treat depression. Unfortunately, many antidepressants have unwanted side effects. Depression is a form of extreme sadness, when you're so sad that it impairs your ability to function. Words starting with anti are the opposite or go against other things. Antidepressants, then, are drugs that fight depression. If you’re depressed, a doctor can prescribe an antidepressant such as Prozac or Zoloft. Antidepressants can improve your mood, but they often have side effects such as weight gain or headaches.

Keep Reading on Vocabulary.com

Vocabulary lists containing antidepressant

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

See Examples For:

The paper notes what it describes as a "stark regional divide" in antidepressant use, with the highest number of prescriptions recorded in North Cumbria and South Yorkshire.

From BBC Aug. 24, 2026

The strongest effect appeared when researchers combined isosteviol, a sweetener used by the food and beverage industry, with the antidepressant duloxetine.

From Science Daily Jul. 17, 2026

A new study finds no evidence that antidepressant medications cause autism.

From Los Angeles Times Jun. 12, 2026

These responses are necessary to educate the public about why antidepressant use is so common.

From Salon May 18, 2026

In the room, Nathan noticed a pamphlet selling antidepressant medication.

From "Healer of the Water Monster" by Brian Young

The Daily Mail reports that one in seven people in England were prescribed antidepressants last year, which it says is an increase of more that 15% in five years.

From BBC Aug. 24, 2026

She is now getting divorced and taking antidepressants.

From BBC Jul. 24, 2026

Any Utah adult can log in to get a refill on cholesterol medications or antidepressants, among other prescriptions.

From The Wall Street Journal Jun. 18, 2026

For comparison, the NNT for SSRIs, the most commonly prescribed antidepressants for moderate-to-severe depression, is around 7.

From Science Daily May 28, 2026

On the seventh day, Dr. Janeway released me from Quiet Oaks under strict orders to continue taking my antidepressants.

From "We Are the Ants" by Shaun David Hutchinson

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