antisense

American  

[an-tee-sens, an-tahy‑] / ˌæn tiˈsɛns, ˌæn taɪ‑ /

adjective

1. of or relating to a gene that is derived from RNA or complementary DNA, is inserted in reverse orientation into a strand of DNA, and is used in genetic engineering to regulate genetic expression of a trait.

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antisense Scientific  

/ ăn′tē-sĕns′,ăn′tī- /

1. Relating to a nucleotide sequence that is complementary to a sequence of messenger RNA. When antisense DNA or RNA is added to a cell, it binds to a specific messenger RNA molecule and inactivates it.

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Etymology

Origin of antisense

First recorded in 1985–90

Example Sentences

The study showed that when the researchers injected a compound called BCC10 linked to specialized genetic tools known as antisense oligonucleotides into mice, it successfully reduced the activity of harmful genes in the brain.

From Science Daily

Similarly, a different antisense oligonucleotide linked to BCC10 greatly reduced another gene, Mapt, which encodes the tau protein and is a target for the treatment of Alzheimer's disease and other dementias.

From Science Daily

The announcement came a week after drugmakers Biogen and Ionis Pharmaceuticals said they are terminating development of BIIB105, an antisense oligonucleotide for ALS that showed disappointing results in an early-stage clinical study.

From Science Magazine

The treatment uses therapeutic molecules called antisense oligonucleotides, or ASOs, that can alter the expression of genes through interactions with RNA, which creates proteins.

From Science Daily

In the new study, the researchers describe how this can be achieved using the so-called "antisense" method.

From Science Daily