antisense

American  

[an-tee-sens, an-tahy-] / ˌæn tiˈsɛns, ˌæn taɪ- /

adjective

1. of or relating to a gene that is derived from RNA or complementary DNA, is inserted in reverse orientation into a strand of DNA, and is used in genetic engineering to regulate genetic expression of a trait.

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antisense Scientific  

/ ăn′tē-sĕns′,ăn′tī- /

1. Relating to a nucleotide sequence that is complementary to a sequence of messenger RNA. When antisense DNA or RNA is added to a cell, it binds to a specific messenger RNA molecule and inactivates it.

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Etymology

Origin of antisense

First recorded in 1985–90

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Example Sentences

See Examples For:

antisense

Researchers have explored gene silencing approaches using siRNAs, antisense oligonucleotides, and CRISPR.

From Science Daily ● Sep. 10, 2026

It is how he characterizes Denali’s TransportVehicle architecture, a modular platform it adapts to carry amyloid antibodies, tau gene-silencing antisense oligonucleotides, or the enzymes that treat some rare, but fatal, genetic disorders.

From Barron's ● Jun. 3, 2026

The announcement came a week after drugmakers Biogen and Ionis Pharmaceuticals said they are terminating development of BIIB105, an antisense oligonucleotide for ALS that showed disappointing results in an early-stage clinical study.

From Science Magazine ● May 22, 2024

In 1992, a geneticist at the University of Hawaii in Honolulu used antisense technology to insert a gene that blocks an enzyme in the caffeine-making pathway.

From Slate ● Jan. 11, 2023

He and other scientists are studying whether other antisense drugs might cause the same problem.

From New York Times ● Dec. 19, 2022

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