ciclosporin

/ ˌsaɪkləʊˈspɔːrɪn /

noun

1. a drug extracted from a fungus and used after organ transplantation to suppress the body's immune mechanisms, and so prevent rejection of an organ

Example Sentences

For children and young people with atopic dermatitis, the most common skin condition in children, the main first line conventional systemic treatments are Methotrexate and Ciclosporin, two immuno-modulatory drugs.

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The patients were given oral doses of methotrexate or ciclosporin and assessed over nine months of treatment and six months after the therapy ended.

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The study found that ciclosporin works faster and reduces disease severity more at 12 weeks but was more expensive, whereas methotrexate was significantly cheaper and led to better objective disease control after 12 weeks and off therapy, with fewer participant-reported flares of atopic dermatitis after treatment had stopped.

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The study led by King's College London, compared the safety and efficacy of ciclosporin with methotrexate in children and young people with this debilitating skin condition.

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However, until now there has been no adequately powered randomised clinical trial evidence in relation to their safety and treatment success for paediatric patients with this condition, and with new therapies being introduced at a high cost, establishing a gold standard for treatment with the conventional systemic therapies like methotrexate and ciclosporin is needed.

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