Creutzfeldt-Jakob disease

American  

[kroits-felt yah-kawp] / ˈkrɔɪts fɛlt ˈyɑ kɔp /

Or Creutzfeldt-Jacob disease

noun

Pathology.

1. a rare, usually fatal brain disorder thought to be caused by an infectious prion and characterized by progressive dementia, blindness, and involuntary movements.

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Creutzfeldt-Jakob disease British  

/ ˈkrɔɪtsfɛlt ˈjɑːkɒp /

noun

1. pathol a fatal slow-developing disease that affects the central nervous system, characterized by mental deterioration and loss of coordination of the limbs. It is thought to be caused by an abnormal prion protein in the brain

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Creutzfeldt-Jakob disease Scientific  

/ kroits′fĕlt-yä′kôp /

1. A rare, usually fatal encephalopathy that occurs most often in middle age and is likely caused by a prion. It is characterized by progressive dementia and gradual loss of muscle control. The disease is named after its discoverers, German pathologist Hans Gerhard Creutzfeldt (1885–1964) and German neurologist Alfons Maria Jakob (1884–1931).

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Etymology

Origin of Creutzfeldt-Jakob disease

1965–70; after German physicians Hans G. Creutzfeldt (1885–1964) and Alfons Jakob (1884–1931)

Example Sentences

Using in vitro and cell culture approaches, animal models and brain samples from patients with Creutzfeldt-Jakob disease, the researchers showed that misfolded prion proteins can trigger the clumping and inactivation of TDP-43.

From Science Daily • Dec. 4, 2023

Anyone can donate their body with the exception of people with Creutzfeldt-Jakob disease, hepatitis B or C, HIV and active tuberculosis.

From Los Angeles Times • May 19, 2023

They are thought to contribute to several progressive brain disorders, including mad cow disease and Creutzfeldt-Jakob disease.

From Textbooks • Jun. 9, 2022

When this illness crossed the species barrier from animal to human in 1996, it took the form of variant Creutzfeldt-Jakob disease, or vCJD.

From The Guardian • Mar. 22, 2018

The discovery suggests that skin samples might be used to improve detection of the disorder, Creutzfeldt-Jakob disease, which now is usually diagnosed with much more difficult procedures, such as brain biopsies or autopsies.

From Seattle Times • Nov. 22, 2017