[kraws-tol-er-uh ns, kros-]

noun Physiology.

the resistance to one or more effects of a substance because of tolerance to a pharmacologically similar substance: a cross-tolerance of some alcoholics to anesthetics.

Nearby words

  1. cross-staff,
  2. cross-sterile,
  3. cross-stitch,
  4. cross-stratification,
  5. cross-string,
  6. cross-town,
  7. cross-trade,
  8. cross-train,
  9. cross-trainer,
  10. cross-utilize

Origin of cross-tolerance

First recorded in 1920–25 Unabridged Based on the Random House Unabridged Dictionary, © Random House, Inc. 2019

Medicine definitions for cross tolerance

cross tolerance


Resistance to an effect or effects of a compound as a result of tolerance previously developed to a pharmacologically similar compound.

The American Heritage® Stedman's Medical Dictionary Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.