[kraws-tol-er-uh ns, kros-]
the resistance to one or more effects of a substance because of tolerance to a pharmacologically similar substance: a cross-tolerance of some alcoholics to anesthetics.
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Origin of cross-tolerance
First recorded in 1920–25
Dictionary.com Unabridged Based on the Random House Unabridged Dictionary, © Random House, Inc. 2019
Resistance to an effect or effects of a compound as a result of tolerance previously developed to a pharmacologically similar compound.
The American Heritage® Stedman's Medical Dictionary Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.