cycloaddition

[sahy-kloh-uh-dish-uhn, sik-loh-]

noun

Chemistry.

1. the formation of a cyclic compound by the addition reaction of unsaturated molecules.

Word History and Origins

Origin of cycloaddition¹

First recorded in 1960–65; cyclo- + addition

Example Sentences

This intermediate step is crucial, as Nagashima remarks: "Our detailed mechanistic studies revealed that the photoexcited borate complex both accelerates the cycloaddition and suppresses the rearomatization that usually occurs in conventional photocycloaddition reactions."

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"We first had to change their specific bonding structure -- carrying out so-called dearomatization -- in order to obtain significantly more reactive intermediates. The subsequent cycloaddition and rearomatization processes ultimately result in the formation of the skeletal-edited compounds."

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The reaction is called copper-catalyzed azide-alkyne cycloaddition -- abbreviated CuAAC and pronounced "quack."

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Later, independently of each other, Meldal and Sharpless discovered “what is now the crown jewel of click chemistry: the copper-catalyzed azide-alkyne cycloaddition. This is an elegant and efficient chemical reaction that is now in widespread use,” the academy said.

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Later, Meldal and Sharpless, independently of each other, discovered “what is now the crown jewel of click chemistry: the copper catalysed azide-alkyne cycloaddition. This is an elegant and efficient chemical reaction that is now in widespread use.”

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