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de novo

American  
[dee noh-voh, dey, dih, de noh-woh] / di ˈnoʊ voʊ, deɪ, dɪ, dɛ ˈnoʊ woʊ /

adverb

  1. anew; afresh; again; from the beginning.

    We reviewed the court’s decision de novo during the rehearing.

  2. independently of external forces; from within; spontaneously.

    Mutations associated with autism often occur de novo rather than through inheritance.


adjective

  1. occurring or arising spontaneously or independently of external forces; spontaneous: de novo synthesis of steroids from cholesterol.

    de novo mutations;

    de novo synthesis of steroids from cholesterol.

  2. made from scratch rather than developed from or based on something preexisting, and hence new, novel, or of a new type: de novo banks.

    de novo protein design;

    de novo banks.

  3. De Novo, noting or related to a type of FDA classification allowing novel medical devices with no precedent on the market to be sold: De Novo classification.

    a De Novo request;

    De Novo classification.

de novo British  
/ diː ˈnəʊvəʊ /

adverb

  1. from the beginning; anew

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

Etymology

Origin of de novo

First recorded in 1620–30; from Latin dē novō “anew, afresh, again”

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

Novel material science also includes de novo chemical combinations for batteries that can store more energy with faster charge cycles and lighter weight.

From The Wall Street Journal

World Liberty Trust filed its de novo application Wednesday with the U.S.

From The Wall Street Journal

Researchers are, therefore, trying to recreate them or to design so-called de novo proteins that do not occur in nature.

From Science Daily

"These de novo or reference-guided assemblers are pretty well-established tools that entail a whole operational pipeline with repeat detection or structural variants' identification being just some of their functionalities," Segarra said.

From Science Daily

One option would be to introduce herbicide resistance genes into the de novo crop and then use herbicides to kill the weeds.

From Science Daily