difficile
Americanadjective
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hard to deal with, satisfy, or please.
-
hard to do; difficult.
Etymology
Origin of difficile
1470–80; < French < Latin difficilis difficult; see dif-, facile
Example Sentences
Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.
"With existing antibiotics, C. difficile sometimes reappears just weeks after treatment," says researcher and lead author Elma Mons.
From Science Daily ● Mar. 11, 2026
Faecal transplants – also known as a trans-poo-tion - are already approved for treating severe diarrhoea caused by Clostridium difficile bacteria.
From BBC ● Jun. 7, 2025
But scientists noticed hints that faecal transplants for C. difficile also seemed to get rid of superbugs.
From BBC ● Jun. 7, 2025
"We found reduced vancomycin susceptibility in C. difficile was associated with lower 30-day sustained clinical response and lower 14-day initial cure rates in the studied patient cohort," said Gonzales-Luna.
From Science Daily ● Apr. 25, 2024
Excessive abdominal noise is an uncommon, but not unprecedented, presenting symptom of infection with the bacteria Clostridium difficile, which can be fatal.
From "Turtles All the Way Down" by John Green
Definitions and idiom definitions from Dictionary.com Unabridged, based on the Random House Unabridged Dictionary, © Random House, Inc. 2023
Idioms from The American Heritage® Idioms Dictionary copyright © 2002, 2001, 1995 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company.
