downregulation

British  

/ ˌdaʊnrɛɡjʊˈleɪʃən /

noun

1. a decrease in sensitivity, through overexposure, to a drug or other chemical caused by a reduction in the number or density of receptors on cell surfaces

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Example Sentences

Furthermore, the researchers examined the effect of Gprc5a downregulation on osteoblast proliferation and differentiation.

From Science Daily

These are off-targets on the mRNA-transcribed regions that represent the downregulation of expression in edited samples compared to wild-type ones.

From Science Daily

This “downregulation” also seems true of genes associated with the ability to hear high frequencies, but that genetic change may have led to the reptiles’ reconfigured ear bones, which make them exquisitely sensitive to vibrations.

From Science Magazine

“Downregulation of HSP47 during hibernation of bears or chronically immobilized patients reduces thromboinflammation” and thus reduces the risk of blood clots, Schattner says.

From Scientific American

Researchers found that early stage melanomas which are at risk of spreading secrete a growth factor which causes the reduction, or downregulation, of certain proteins in the skin overlying the tumour.

From BBC