Dictionary.com
Thesaurus.com

downregulation

British  
/ ˌdaʊnrɛɡjʊˈleɪʃən /

noun

  1. a decrease in sensitivity, through overexposure, to a drug or other chemical caused by a reduction in the number or density of receptors on cell surfaces

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

See Examples For:

These are off-targets on the mRNA-transcribed regions that represent the downregulation of expression in edited samples compared to wild-type ones.

From Science Daily Oct. 23, 2023

Researchers found that early stage melanomas which are at risk of spreading secrete a growth factor which causes the reduction, or downregulation, of certain proteins in the skin overlying the tumour.

From BBC Jan. 14, 2022

Adipose-specific loss of LSD1 in mice causes downregulation of BAT-specific genes and aberrant induction of genes typically found in white adipose tissue6.

From Nature Apr. 30, 2019

This process is called downregulation, and it allows cells to become less reactive to the excessive hormone levels.

From Textbooks Jun. 19, 2013

Thus, their downregulation, or reduction in response, would allow the content of the limbic systems that process emotion and perhaps sensory cortices to play a relatively more dominant role.

From Scientific American May 15, 2012

Vocabulary.com logo
by dictionary.com

Dictionary.com's Learning Companion

Go beyond just looking up words.
Remember them forever with VocabTrainer.

Start training