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downregulation

British  
/ ˌdaʊnrɛɡjʊˈleɪʃən /

noun

  1. a decrease in sensitivity, through overexposure, to a drug or other chemical caused by a reduction in the number or density of receptors on cell surfaces

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

Example Sentences

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These are off-targets on the mRNA-transcribed regions that represent the downregulation of expression in edited samples compared to wild-type ones.

From Science Daily • Oct. 23, 2023

Researchers found that early stage melanomas which are at risk of spreading secrete a growth factor which causes the reduction, or downregulation, of certain proteins in the skin overlying the tumour.

From BBC • Jan. 14, 2022

Adipose-specific loss of LSD1 in mice causes downregulation of BAT-specific genes and aberrant induction of genes typically found in white adipose tissue6.

From Nature • Apr. 30, 2019

These drugs reflect another role of cortisol—the downregulation of the immune system, which inhibits the inflammatory response.

From Textbooks • Jun. 19, 2013

Thus, their downregulation, or reduction in response, would allow the content of the limbic systems that process emotion and perhaps sensory cortices to play a relatively more dominant role.

From Scientific American • May 15, 2012

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