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downregulation

British  
/ ˌdaʊnrɛɡjʊˈleɪʃən /

noun

  1. a decrease in sensitivity, through overexposure, to a drug or other chemical caused by a reduction in the number or density of receptors on cell surfaces

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

Example Sentences

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Furthermore, the researchers examined the effect of Gprc5a downregulation on osteoblast proliferation and differentiation.

From Science Daily ● Jun. 18, 2024

Researchers found that early stage melanomas which are at risk of spreading secrete a growth factor which causes the reduction, or downregulation, of certain proteins in the skin overlying the tumour.

From BBC ● Jan. 14, 2022

Cohesin loss eliminates all loop domains, leading to links among superenhancers and downregulation of nearby genes.

From Nature ● Sep. 26, 2017

These drugs reflect another role of cortisol—the downregulation of the immune system, which inhibits the inflammatory response.

From Textbooks ● Jun. 19, 2013

Thus, their downregulation, or reduction in response, would allow the content of the limbic systems that process emotion and perhaps sensory cortices to play a relatively more dominant role.

From Scientific American ● May 15, 2012

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