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  • drug
    drug
    noun
    a chemical substance used in the treatment, cure, prevention, or diagnosis of disease or used to otherwise enhance physical or mental well-being.
  • Drug
    Drug
    noun
    the cosmic principle of disorder and falsehood.
Synonyms

drug

1 American  
[druhg] / drʌg /

noun

  1. Pharmacology. a chemical substance used in the treatment, cure, prevention, or diagnosis of disease or used to otherwise enhance physical or mental well-being.

  2. (in federal law)

    1. any substance recognized in the official pharmacopoeia or formulary of the nation.

    2. any substance intended for use in the diagnosis, cure, mitigation, treatment, or prevention of disease in humans or other animals.

    3. any article, other than food, intended to affect the structure or any function of the body of humans or other animals.

    4. any substance intended for use as a component of such a drug, but not a device or a part of a device.

  3. a habit-forming medicinal or illicit substance, especially a narcotic.

  4. drugs,

    1. chemical substances prepared and sold as pharmaceutical items, either by prescription or over the counter.

    2. personal hygienic items sold in a drugstore, as toothpaste, mouthwash, etc.

  5. Obsolete. any ingredient used in chemistry, pharmacy, dyeing, or the like.


verb (used with object)

drugged, drugging
  1. to administer a medicinal drug to.

  2. to stupefy or poison with a drug.

  3. to mix (food or drink) with a drug, especially a stupefying, narcotic, or poisonous drug.

  4. to administer anything nauseous to.

verb phrase

  1. drug up to take a drug, especially an illegal drug: athletes who drug up in the off-season.

    kids hiding under the school bleachers to drug up;

    athletes who drug up in the off-season.

idioms

  1. drug on the market, a commodity that is overabundant or in excess of demand in the market. Also drug in the market.

drug 2 American  
[druhg] / drʌg /

verb

Nonstandard: Chiefly Midland and Southern U.S.
  1. a simple past tense and past participle of drag.


Drug 3 American  
[droog] / drʊg /

noun

Zoroastrianism.
  1. the cosmic principle of disorder and falsehood.


drug British  
/ drʌɡ /

noun

  1. any synthetic, semisynthetic, or natural chemical substance used in the treatment, prevention, or diagnosis of disease, or for other medical reasons

  2. a chemical substance, esp a narcotic, taken for the pleasant effects it produces

  3. a commodity available in excess of the demands of the market

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

verb

  1. to mix a drug with (food, drink, etc)

  2. to administer a drug to

  3. to stupefy or poison with or as if with a drug

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012
drug Scientific  
/ drŭg /
  1. A chemical substance, especially one prescribed by a medical provider, that is used in the diagnosis, treatment, or prevention of a condition or disease. Drugs are prescribed for a limited amount of time, as for an acute infection, or on a regular basis for chronic disorders, such as hypertension.

  2. A chemical substance such as a narcotic or a hallucinogen that affects the central nervous system and is used recreationally for perceived desirable effects on personality, perception, or behavior. Many recreational drugs are used illicitly and can be addictive.


Other Word Forms

Etymology

Origin of drug1

First recorded in 1300–50; Middle English drogges (plural), from Middle French drogue, of obscure origin

Origin of Drug3

From the Avestan word drauga

Explanation

A drug is a medicine. Before you travel to India, your doctor may prescribe a drug to protect you from getting malaria. A substance that makes a change in your body is a drug. Most often, a drug is medicine prescribed by a doctor to protect a patient from illness, cure them, or relieve their pain. Drug also means an illegal substance taken simply for the way it makes the user feel. Drug is also a verb that describes both taking illegal drugs and giving someone a drug secretly, such as slipping it into their food or drink.

Keep Reading on Vocabulary.com

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

A new study suggests that Wegovy, the popular weight loss drug, may carry a higher risk of a rare eye condition that can lead to sudden vision loss compared with other semaglutide medications.

From Science Daily • May 23, 2026

Its drug remdesivir, which was used to treat Covid, also inhibited the Bundibugyo strain in one lab study.

From The Wall Street Journal • May 22, 2026

However, Geisbet says it is encouraging to hear that the WHO will be prioritising the use of the experimental anti-viral drug Obladesivir, under strict protocols.

From BBC • May 22, 2026

CEO Robert Davis asserted earlier this year that the company had been building a “patent wall” to cover new indications and drug combinations, with some patents extended to 2029.

From Barron's • May 22, 2026

To confirm the diagnosis, samples of each patient’s TB had to be regrown in cultures and tested for drug susceptibility.

From "Mountains Beyond Mountains" by Tracy Kidder and Michael French

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