ethionamide

[eth-ee-on-uh-mahyd]

noun

Pharmacology.

1. an antimicrobial substance, C 8 H 10 N 2 S, used against susceptible Mycobacterium tuberculosis in combination with other drugs in the treatment of any active form of tuberculosis.

Word History and Origins

Origin of ethionamide¹

First recorded in 1960–65; e(thyl) + thion(ic) + amide

Example Sentences

Thus, they not only attack the pathogen's virulence factors, but also enhance the activity of monooxygenases -- enzymes required for the activation of the conventional antibiotic ethionamide.

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Ethionamide is a drug that has been used for many decades to treat TB.

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The research has been published in the article 'Discovery of dual-active ethionamide boosters inhibiting the Mycobacterium tuberculosis ESX-1 secretion system' in Cell Chemical Biology.

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To reduce the likelihood of M. tuberculosis developing a mutation in the ethA2 gene to again outwit the drug, the authors suggest pulsing doses of SMARt-420 during continual ethionamide treatment.

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Déprez suggests that if SMARt-420 increases ethionamide potency in humans, the drug pairing might ultimately reduce the amount of ethionamide needed to treat TB, potentially reducing side effects.

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