glycosylation

/ ˌɡlaɪkəʊsəˈleɪʃən /

noun

1. the process by which sugars are chemically attached to proteins to form glycoproteins

Word History and Origins

Origin of glycosylation¹

from glycosyl radical derived from glycose + _-ation

Example Sentences

This sugar modification, called glycosylation, is crucial for many biological processes, including immune response.

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The study shows that a significant reduction of glycosylation -- a type of protein modification -- on T cell surfaces correlates with increases in CD8+ immune cells infiltrating tumors.

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"In B4GALT3 knockout or KO mice, we demonstrated the potential of manipulating glycosylation of the T cell surface as a new approach to cancer immunotherapy," says Heng Wei of Kyoto University's Graduate School of Medicine.

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Several scientists, including Srivastava, are developing open databases — such as UniCarbKB, GlyTouCan and the Glycan Mass Spectral Database — that can be used to identify sugars and common glycosylation sites on proteins.

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“You can quickly see which proteins’ glycosylation patterns are altered in cirrhosis, cancer or other diseases,” he says.

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