Be in charge of, lead, as in She headed up the commission on conservation. [Colloquial; mid-1900s]
THINK YOU’VE GOT A HANDLE ON THIS US STATE NICKNAME QUIZ?
Words nearby head up
Example sentences from the Web for head up
This kept the wearer of the suit always in an upright, head-up position.The Bluff of the Hawk|Anthony Gilmore
(c) It remains where it is, but adopts a head-up posture: the attacker usually then shows upright flight.
Head-up posturing and upright flight are not presently recognized components of the behavior of the Bell Vireo.