hemizygous

/ ˌhɛmɪˈzaɪɡəs /

adjective

1. genetics (of a chromosome or gene) not having a homologue; not paired in a diploid cell

Example Sentences

Mice were then intercrossed to obtain ‘CPPSML’ males with homozygous status of Pten, p53, and Smad4, heterozygous status of mTmG and LSL-LUC, and hemizygous status of PB-Cre.

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Inoculation with brain homogenates from people with the neurodegenerative condition multiple system atrophy, in which α-synuclein forms intracellular amyloid deposits, was reported to produce a neurodegenerative illness in transgenic mice that are hemizygous for a transgene expressing a mutant α-synuclein.

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This difference is expected because the population size of the chromosome is three quarters that of autosomes, and the chromosome can experience greater purifying selection because of exposure of deleterious recessive alleles in hemizygous males.

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New -linked mutations are directly exposed to selection each generation in hemizygous males, and the chromosome has greater recombination than autosomes; both of these factors could contribute to this observation.

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Because wild-type female hybrids are never hemizygous for chromosomal regions, it is essential to consider how the putative DM HI regions identified in their screen would function in normal hybrids.

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