[ his-tuh-meen, -min ]
/ ˈhɪs təˌmin, -mɪn /


Biochemistry, Physiology. a heterocyclic amine, C5H9N3, released by mast cells when tissue is injured or in allergic and inflammatory reactions, causing dilation of small blood vessels and smooth muscle contraction.
Pharmacology. a commercial form of this compound, obtained from histidine and used chiefly in the diagnosis of gastric and circulatory functions.



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Also his·ta·min [his-tuh-min] /ˈhɪs tə mɪn/.
Compare antihistamine.

Origin of histamine

First recorded in 1910–15; hist(idine) + -amine


his·ta·min·ic [his-tuh-min-ik] /ˌhɪs təˈmɪn ɪk/, adjective
Dictionary.com Unabridged Based on the Random House Unabridged Dictionary, © Random House, Inc. 2020

British Dictionary definitions for histaminic

/ (ˈhɪstəˌmiːn, -mɪn) /


an amine formed from histidine and released by the body tissues in allergic reactions, causing irritation. It also stimulates gastric secretions, dilates blood vessels, and contracts smooth muscle. Formula: C 5 H 9 N 3See also antihistamine

Derived forms of histamine

histaminic (ˌhɪstəˈmɪnɪk), adjective

Word Origin for histamine

C20: from hist (idine) + -amine
Collins English Dictionary - Complete & Unabridged 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

Medical definitions for histaminic

[ hĭstə-mēn′, -mĭn ]


A physiologically active depressor amine found in plant and animal tissue, derived from histidine by decarboxylation and released from cells in the immune system as part of an allergic reaction. It is a powerful stimulant of gastric secretion, constrictor of bronchial smooth muscle, and vasodilator.

Other words from histamine

his′ta•minic (-mĭnĭk) adj.
The American Heritage® Stedman's Medical Dictionary Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.

Scientific definitions for histaminic

[ hĭstə-mēn′ ]

An organic compound found widely in animals and plants that in humans and other mammals is released as part of the body's immune response, causing physiological changes including dilation of the blood vessels, contraction of smooth muscle (as in the airways), and increased gastric acid secretion. The itching and sneezing typical of respiratory allergies are caused by the release of histamine. Chemical formula: C5H9N3
The American Heritage® Science Dictionary Copyright © 2011. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.