holoenzyme

[hol-oh-en-zahym]

noun

1. an enzyme complete in both its apoenzyme and coenzyme components.

holoenzyme

/ ˌhɒləʊˈɛnzaɪm /

noun

1. an active enzyme consisting of a protein component (apoenzyme) and its coenzyme

Word History and Origins

Origin of holoenzyme¹

First recorded in 1940–45; holo- + enzyme

Example Sentences

Mediator structure and rearrangements required for holoenzyme formation.

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These activity differences are explained by the fact that CaMKII functions as a dodecamer, and the linker length determines the compactness and thus the substrate accessibility of the holoenzyme—enzymes with long linkers have higher activity.

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Conceivably, such a phenomenon could reflect migration to ‘transcription factories’—preassembled nuclear subcompartments that contain RNA polymerase II holoenzyme.

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