• synonyms


[hahy-druh-klawr-ahyd, -id, -klohr-]
  1. a salt, especially of an alkaloid, formed by the direct union of hydrochloric acid with an organic base that makes the organic constituent more soluble.
Show More

Origin of hydrochloride

First recorded in 1820–30; hydro-2 + chloride
Dictionary.com Unabridged Based on the Random House Unabridged Dictionary, © Random House, Inc. 2018

Examples from the Web for hydrochloride

Historical Examples

  • The nitrate and hydrochloride are at present much used in pharmacy.

    Poisons: Their Effects and Detection

    Alexander Wynter Blyth

  • The hydrochloride is soluble in alcohol and in water, melting-point about 205°.

  • The hydrochloride crystallises in white plates, and has a melting-point of 192°.

  • Hydrochloride of nicotine is more easily volatilised than the pure base.

  • It gives a precipitate with potassium iodide if a solution of the hydrochloride be used.

British Dictionary definitions for hydrochloride


  1. a quaternary salt formed by the addition of hydrochloric acid to an organic base, such as aniline hydrochloride, [C 6 H 5 NH 3 ] + Cl -
Show More
Collins English Dictionary - Complete & Unabridged 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

hydrochloride in Medicine


  1. A compound resulting from the reaction of hydrochloric acid with an organic base.
Show More
The American Heritage® Stedman's Medical Dictionary Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.

hydrochloride in Science


  1. A salt containing the group HCl. Many important drugs are hydrochlorides.
Show More
The American Heritage® Science Dictionary Copyright © 2011. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.