[ hahy-per-ker-uh-toh-sis ]
/ ˌhaɪ pərˌkɛr əˈtoʊ sɪs /


  1. proliferation of the cells of the cornea.
  2. a thickening of the horny layer of the skin.
Also called x-disease. Veterinary Pathology. a disease of cattle resulting from their physical contact with or eating of objects or food contaminated by wood preservatives or machinery lubricants containing highly chlorinated naphthalenes, characterized by thickening and hardening of the skin, abnormal secretion of tears and saliva, and diarrhea.

Nearby words

  1. hyperion,
  2. hyperirritability,
  3. hyperisotonic,
  4. hyperkalemia,
  5. hyperkalemic periodic paralysis,
  6. hyperkeratosis lenticularis perstans,
  7. hyperketonemia,
  8. hyperketonuria,
  9. hyperkinemia,
  10. hyperkinesia

Origin of hyperkeratosis

From New Latin, dating back to 1835–45; see origin at hyper-, keratosis

Related formshy·per·ker·a·tot·ic [hahy-per-ker-uh-tot-ik] /ˌhaɪ pərˌkɛr əˈtɒt ɪk/, adjective

Dictionary.com Unabridged Based on the Random House Unabridged Dictionary, © Random House, Inc. 2019

British Dictionary definitions for hyperkeratotic


/ (ˌhaɪpəˌkɛrəˈtəʊsɪs) /


pathol overgrowth and thickening of the outer layer of the skin
Derived Formshyperkeratotic (ˌhaɪpəˌkɛrəˈtɒtɪk), adjective

Collins English Dictionary - Complete & Unabridged 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

Medicine definitions for hyperkeratotic


[ hī′pər-kĕr′ə-tōsĭs ]

n. pl. hy•per•ker•a•to•ses (-sēz)

Hypertrophy of the cornea or the horny layer of the skin.hyperkeratinization
Related formshy′per•ker′a•totic (-tŏtĭk) adj.

The American Heritage® Stedman's Medical Dictionary Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.