[ hahy-per-splee-niz-uh m, -splen-iz- ]
/ ˌhaɪ pərˈspli nɪz əm, -ˈsplɛn ɪz- /

noun Pathology.

an abnormal condition characterized by an enlarged spleen that prematurely destroys red blood cells or platelets.

Origin of hypersplenism

First recorded in 1910–15; hyper- + splen- + -ism
Also called hy·per·sple·ni·a [hahy-per-splee-nee-uh] /ˌhaɪ pərˈspli ni ə/.

Related forms

hy·per·sple·nic, adjective
Dictionary.com Unabridged Based on the Random House Unabridged Dictionary, © Random House, Inc. 2019

Medicine definitions for hypersplenism


[ hī′pər-splĕnĭz′əm, -splēnĭz′əm ]


A condition in which the hemolytic action of the spleen is greatly increased.
The American Heritage® Stedman's Medical Dictionary Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.