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immunodeficiency

American  
[im-yuh-noh-di-fish-uhn-see, ih-myoo-] / ˌɪm jə noʊ dɪˈfɪʃ ən si, ɪˌmju- /

noun

immunodeficiencies plural
  1. impairment of the immune response, predisposing to infection and certain malignancies.


immunodeficiency British  
/ ˌimjʊnəʊdɪˈfɪʃənsɪ /

noun

  1. a deficiency in or breakdown of a person's immune system

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

immunodeficiency Scientific  
/ ĭm′yə-nō-dĭ-fĭshən-sē,ĭ-myo̅o̅′- /
  1. The inability to produce a normal immune response, caused by an acquired or inherited disease.


Other Word Forms

Derived Forms

Inflected Forms

Nouns

Etymology

Origin of immunodeficiency

First recorded in 1970–75; immuno- + deficiency

Explanation

When someone's body can't protect itself from infection the way it should, they suffer from an immunodeficiency. Many patients being treated for cancer have immunodeficiencies. Your immune system is the network of cells that works to fight infection throughout your body, and when it isn't functioning well, the result is immunodeficiency. The word is rooted in the Latin immunis, "exempt," and deficere, "to fail." In other words, immunodeficiency is a failure of the system that keeps you free from infections and illness. Various diseases, genetic conditions, and medications can result in this risky situation.

Keep Reading on Vocabulary.com

Vocabulary lists containing immunodeficiency

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

See Examples For:

The growth was driven by strong sales of products for treatment of HIV, or human immunodeficiency virus, which rose 10% to $5 billion, as well as the drugs Trodelvy and Livdelzi.

From The Wall Street Journal May 7, 2026

They point out that malnutrition is the leading cause of immunodeficiency worldwide.

From Science Daily Jan. 12, 2024

HIV is human immunodeficiency virus, which damages the cells in your immune system and weakens your ability to fight everyday infections and diseases.

From BBC Jul. 25, 2023

The legal dispute centered on who devised the idea of using a Gilead medication for people at high risk of contracting H.I.V., or the human immunodeficiency virus, which causes AIDS.

From New York Times May 9, 2023

Moderna also is developing potential vaccines for respiratory syncytial virus, or RSV, and the human immunodeficiency virus that causes AIDS.

From Seattle Times Apr. 11, 2023

People who have rare and complex chronic conditions, such as immunodeficiencies, rely on life-sustaining medicine developed from plasma donations – including Julie Jolley.

From Seattle Times Feb. 2, 2022

Although Covid presents relatively few risks to children and vaccinated adults under 50, it presents more to older people and some with specific immunodeficiencies.

From New York Times Dec. 10, 2021

These are the pandemic experiences of immunocompromised people—those with organ transplants or certain cancers, those on chemotherapy or immunosuppressant drugs, those with genetic immunodeficiencies, those with other issues that suppress their immune systems.

From Slate Oct. 12, 2021

Its intravenous form is FDA-licensed for six conditions, including primary immunodeficiencies; Kawasaki disease, which causes inflammation in the blood vessels; preventive care after bone marrow transplants; and a neurological condition called chronic inflammatory demyelinating polyneuropathy.

From Washington Post Sep. 20, 2019

Inherited immunodeficiencies arise from gene mutations that affect specific components of the immune response.

From Textbooks Jun. 19, 2013

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