isolate

American  

[ahy-suh-leyt, ahy-suh-lit, -leyt] / ˈaɪ səˌleɪt, ˈaɪ sə lɪt, -ˌleɪt /

verb (used with object)

isolated, isolating

1. to set or place apart; detach or separate so as to be alone.

2. Medicine/Medical. to keep (an infected person) from contact with noninfected persons; quarantine.

3. Chemistry, Bacteriology. to obtain (a substance or microorganism) in an uncombined or pure state.

4. Electricity. to insulate.

5. Television. to single out (a person, action, etc.) for a camera closeup.

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noun

1. a person, thing, or group that is set apart or isolated, as for purposes of study.

2. Psychology. a person, often shy or lacking in social skills, who avoids the company of others and has no friends within a group.

3. Biology. an inbreeding population that is isolated from similar populations by physiological, behavioral, or geographic barriers.

4. Also called language isolate.  Linguistics. a language with no demonstrable genetic relationship, as Basque.

5. something that has been isolated, as a by-product in a manufacturing process.

   an isolate of soy flour.

adjective

1. isolated; alone.

isolate British  

verb

1. to place apart; cause to be alone

2. med to quarantine (a person or animal) having or suspected of having a contagious disease

3. to obtain (a compound) in an uncombined form

4. to obtain pure cultures of (bacteria, esp those causing a particular disease)

5. electronics to prevent interaction between (circuits, components, etc); insulate

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noun

1. an isolated person or group

Other Word Forms

• isolability noun
• isolable adjective
• isolator noun
• reisolate verb (used with object)
• unisolate verb (used with object)

Etymology

Origin of isolate

First recorded in 1800–10; back formation from isolated

Explanation

When you remove or set apart one thing from others, you isolate it. You could isolate yourself from people by living in a remote hut or, if you're a biologist, you could isolate a chromosome. The verb isolate comes from the adjective isolated, which comes from the Latin insulatas, meaning “made into an island.” You may have heard the John Donne quote, “No man is an island.” Donne was claiming that no matter how much you might try to isolate yourself from the rest of humanity, in the end people are all connected to one another. Humanity’s need for connectedness may, in fact, be illustrated by the fact that jailers frequently isolate criminals as punishment.

Example Sentences

Upstream production, or the process of getting oil out of the ground, is relatively straightforward; it’s easier to isolate the problem and restart the system quickly.

From MarketWatch • Apr. 11, 2026

Social media companies argue that blanket bans will be ineffective, difficult to enforce and could isolate vulnerable teenagers.

From BBC • Apr. 8, 2026

Military strategists say that in an invasion or blockade of Taiwan, China could isolate the island nation by using mines.

From The Wall Street Journal • Mar. 17, 2026

Researchers can later isolate these tagged cells from living cell populations using techniques such as flow cytometry.

From Science Daily • Mar. 10, 2026

And if you do use two, they should act like parentheses to isolate a remark from the rest of the sentence.

From "Woe Is I" by Patricia T. O'Conner

Related Words

• confine
• detach
• disconnect
• disengage
• divide
• insulate
• remove
• segregate
• separate
• sequester