Become discouraged, as in The rescuers worked hard for the first few hours, but then they lost heart. This term uses heart in the sense of “courage” or “spirit.” [Mid-1800s] Also see lose one's heart to.
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How to use lose heart in a sentence
A lot of people ring in the New Year with vows to lose weight and exercise.How Skinny Is Too Skinny? Israel Bans ‘Underweight’ Models|Carrie Arnold|January 8, 2015|DAILY BEAST
The questions going through my mind are: How on earth are there Kalashnikovs and rocket launchers in the heart of Paris?Ayaan Hirsi Ali: Our Duty Is to Keep Charlie Hebdo Alive|Ayaan Hirsi Ali|January 8, 2015|DAILY BEAST
But at the heart of this “Truther” conspiracy theory is the idea that “someone” wants to destroy Bill Cosby.
She fills her characters up—strong women beating back against a sexist system—with so much heart.Oscars 2015: The Daily Beast’s Picks, From Scarlett Johansson to ‘Boyhood’|Marlow Stern|January 6, 2015|DAILY BEAST
One specific kind of emergency is at the heart of this, such as when an airplane suffers a loss of stability at night.Flight 8501 Poses Question: Are Modern Jets Too Automated to Fly?|Clive Irving|January 4, 2015|DAILY BEAST
The blood that accused his friend in his heart, rushed to his face, when he repeated what had been told him.The Pastor's Fire-side Vol. 3 of 4|Jane Porter
After all, may not even John Burns be human; may not Mr. Chamberlain himself have a heart that can feel for another?God and my Neighbour|Robert Blatchford
Turn away from sin and order thy hands aright, and cleanse thy heart from all offence.
Her heart fluttered violently with fear as she saw that he stepped out after her, and walked by her side toward the house.Checkmate|Joseph Sheridan Le Fanu
For of sadness cometh death, and it overwhelmeth the strength, and the sorrow of the heart boweth down the neck.