lysate

[lahy-seyt]

noun

Biochemistry.

1. the mixture of substances formed by the lysis of cells.

Word History and Origins

Origin of lysate¹

First recorded in 1920–25; lys(is) + -ate ¹

Example Sentences

Mice vaccinated with this nanoparticle lysate vaccine were later exposed to melanoma, pancreatic ductal adenocarcinoma, or triple-negative breast cancer cells.

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To simplify the process, the researchers tested a second version using killed tumor cells, called tumor lysate, derived directly from the cancer itself.

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The horseshoe crabs are valuable because their blood can be manufactured into limulus amebocyte lysate, or LAL, that is used to detect pathogens in indispensable medicines such as injectable antibiotics.

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“I certainly don’t believe in killing animals unnecessarily. And you can argue, if you want to, against animal research, until it impacts your own health, of course. But the argument that the lysate industry is depopulating the crab population is just not correct.”

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Last summer, as coronavirus infection rates continued to rise, a group of researchers from Eli Lilly, Bristol Myers Squibb, Pfizer and Roche-Genentechpublished a research report that compared the two products — limulus amebocyte lysate, or LAL, which is made from horseshoe crab blood, and the synthetic product, called recombinant Factor C assay, or rFC.

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