macromutation

American  

[mak-roh-myoo-tey-shuhn] / ˌmæk roʊ mjuˈteɪ ʃən /

noun

Genetics.

1. a mutation that has a profound effect on the resulting organism, as a change in a regulatory gene that controls the expression of many structural genes.

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Etymology

Origin of macromutation

macro- + mutation