[ mak-roh-myoo-tey-shuhn ]
/ ˌmæk roʊ myuˈteɪ ʃən /
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a mutation that has a profound effect on the resulting organism, as a change in a regulatory gene that controls the expression of many structural genes.
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Dictionary.com Unabridged Based on the Random House Unabridged Dictionary, © Random House, Inc. 2021
How to use macromutation in a sentence
The first animal to be segmented—to go from just a single body to a body with two segments—must have been a macromutation.