a mutation that has a profound effect on the resulting organism, as a change in a regulatory gene that controls the expression of many structural genes.
Origin of macromutation
Dictionary.com Unabridged Based on the Random House Unabridged Dictionary, © Random House, Inc. 2019
Examples from the Web for macromutation
Contemporary Examples of macromutation
The first animal to be segmented—to go from just a single body to a body with two segments—must have been a macromutation.Rediscovering Richard Dawkins: An Interview
September 23, 2013