major depressive disorder

American  

[may-jer-di-pres-iv-dis-awr-der] / ˈmeɪ dʒər dɪˈprɛs ɪv dɪsˈɔr dər /

noun

1. Psychiatry. an affective disorder characterized by a sustained period of low mood, diminished self-esteem, and reduced interest in normally enjoyable activities.

---

Example Sentences

See Examples For:

major depressive disorder

Clancy was clinically diagnosed with major depressive disorder by multiple professionals: McLean Hospital psychiatrist Dr. Alia Goodheart, outpatient psychiatrist Dr. Jennifer Tufts and prosecution expert Dr. Avram Mack.

From Salon ● Sep. 2, 2026

Two of the five trials, both involving women with major depressive disorder, found that creatine provided additional benefits.

From Science Daily ● Jun. 30, 2026

Earlier studies have shown that people diagnosed with major depressive disorder have lower levels of Reelin in their brains.

From Science Daily ● Feb. 2, 2026

Antidepressants are typically prescribed for people with major depressive disorder.

From The Wall Street Journal ● Nov. 11, 2025

A group of 82 participants with major depressive disorder was assessed using two innovative methods.

From Science Daily ● Nov. 25, 2024