major depressive disorder

American  

[may-jer-di-pres-iv-dis-awr-der] / ˈmeɪ dʒər dɪˈprɛs ɪv dɪsˈɔr dər /

noun

1. Psychiatry. an affective disorder characterized by a sustained period of low mood, diminished self-esteem, and reduced interest in normally enjoyable activities.

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Example Sentences

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major depressive disorder

Clancy was clinically diagnosed with major depressive disorder by multiple professionals: McLean Hospital psychiatrist Dr. Alia Goodheart, outpatient psychiatrist Dr. Jennifer Tufts and prosecution expert Dr. Avram Mack.

From Salon ● Sep. 2, 2026

Among children whose mothers had a history of major depressive disorder, growing depressive symptoms were associated with increased attention to sad faces.

From Science Daily ● Jun. 17, 2026

Diagnoses of major depressive disorder were determined using the Mini International Neuropsychiatric Interview.

From Science Daily ● Feb. 12, 2026

Patients living with major depressive disorder, including those who have not improved with commonly prescribed antidepressants, may benefit from short-term nitrous oxide treatment, according to a large meta-analysis led by the University of Birmingham.

From Science Daily ● Dec. 2, 2025

Xenon Pharmaceuticals says it paused trials for azetukalner in major depressive disorder and bipolar depression following ‘adverse events.’

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