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major depressive disorder

American  
[may-jer-di-pres-iv-dis-awr-der] / ˈmeɪ dʒər dɪˈprɛs ɪv dɪsˈɔr dər /

noun

  1. Psychiatry. an affective disorder characterized by a sustained period of low mood, diminished self-esteem, and reduced interest in normally enjoyable activities.


Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

Biohaven tumbles after its drug, BHV-7000, fails to meet the primary endpoint in a phase 2 trial for major depressive disorder.

From Barron's • Dec. 26, 2025

Of these participants, 259 had schizophrenia and 177 had affective disorders that included bipolar disorder and major depressive disorder with psychosis.

From Science Daily • Dec. 4, 2025

Antidepressants are typically prescribed for people with major depressive disorder.

From The Wall Street Journal • Nov. 11, 2025

Behind its glassy doors is something rare: A community run by people with serious mental health conditions such as schizophrenia, bipolar disorder and major depressive disorder.

From Los Angeles Times • Nov. 2, 2024

Treatment-resistant depression affects approximately 30 percent of patients diagnosed with major depressive disorder.

From Salon • Aug. 6, 2024

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