missense

American  

[mis-sens] / ˈmɪsˌsɛns /

adjective

1. Genetics. relating to or being a genetic mutation involving a nucleotide change that alters a codon and results in the substitution of one amino acid for another in the protein.

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missense Scientific  

/ mĭs′sĕns′ /

1. Relating to a mutation that changes a codon for one amino acid into a codon for a different amino acid.

2. See more at point mutation

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Example Sentences

The tool's predictions for missense variants across the entire genome are accessible for non-commercial use and analysis at https://itanlab.shinyapps.io/goflof/.

From Science Daily • Dec. 14, 2023

Among the cohort, 46 patients had missense variants of the gene U2AF2 and six patients had variants of the gene PRPF19.

From Science Daily • Nov. 28, 2023

So when researchers and doctors find a missense mutation they’ve never seen before, it can be difficult to know what to make of it.

From Scientific American • Sep. 21, 2023

A missense mutation can stop the replication or reading of that strand.

From Textbooks • Jun. 9, 2022

And there are few ways to assess predictive algorithms, particularly those that go beyond evaluating missense mutations, says John Moult, a bioinformatician at the University of Maryland in Rockville.

From Nature • Feb. 8, 2012