a system of substitution that uses only one cipher alphabet in a cryptogram so that each plaintext letter is always represented by the same cipher.
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- monoamine oxidase,
- monoamine oxidase inhibitor,
Compare polyalphabetic substitution.
Origin of monoalphabetic substitution
1935–40; mono- + alphabetic
Dictionary.com Unabridged Based on the Random House Unabridged Dictionary, © Random House, Inc. 2019